Benign cancer of blood vessels, Modificările funcţionale ale celulelor canceroase în raport cu celulele normale


Horhoianu, M. Abstract Since the first description of uterine artery embolisation for the treatment of symptomatic fibroids of the uterus inthis minimally invasive procedure has been increasingly performed in many countries.

Transcatheter embolisation of the uterine arteries feeding large fibroids is a minimally invasive technique. This paper presents benign cancer of blood vessels combined endovascular and surgical therapy in the treatment of uterine fibroma.

Modificările funcţionale ale celulelor canceroase în raport cu celulele normale

The purpose of this therapy is saving the reproductive function of the uterus even in cases with very large fibromas or located in areas with difficult access, in which hysterectomy would have been needed. The therapy has a high rate of success, it is accompanied by disappearance of the symptoms and it has a low risk of intra- and post-operatory complications.

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The first step is the embolisation of uterine arteries — benign cancer of blood vessels safe therapy of uterine fibroma.

The procedure eliminates the risk of post-miomectomy relapse through the symultaneous devascularisation of all fibroma nodules, even of the very small ones which are unapparent clinically or imagistically.


The post-embolisation surgical intervention is undertaken in conditions of operative comfort, with minimal bleeding; it eliminates the need for blood transfusions and diminishes the duration of intervention. Three representative cases where this therapy has been successfully applied are presented in this article.

Secundare metastatic tumora este acelaşi tip de cancer ca tumorii primare. I shrank a cancer tumor with six drops of our drug. Am micșorat tumoarea canceroasă cu șase picături din medicamentul nostru. It's a treatment to shrink cancer tumors and make them inactive. E un tratament care micșorează tumoarea canceroasă și o face inactivă.

The embolisation of the uterine arteries represents an efficient therapy of the uterine fibroma, with very good results noted in the speciality literature. In many cases benign cancer of blood vessels is asymptomatic and it is discovered incidentally by a pelvic ultrasound imaging.

In time, single or multiple fibromas may grow and become symptomatic by abundant, long and painful menstruations, a sensation of pressure in the abdomen, urinary frequency and back pain. These symptoms may respond initially to medical therapy including gonadotropin-releasing hormone agonistsbut often this therapy is not enough and they require surgical treatment.

The human body is composed of trillions of cells, which constantly grow, divide and die. For the most part, cells are healthy and perform vital functions, but sometimes they do not form or behave properly. Cancer begins when an abnormal cell grows and does not stop dividing.

It often causes infertility or miscarriage. The standard approach of treatment of fibroid uteri includes as well surgical therapy which consists of uterus resection hysterectomy either transabdominal or transvaginal and sometimes resection of the ovaries.

Following that intervention, the woman loses her gestational function.

Hemangiom sau varicelor

Therefore, for young women who whish to preserve their fertility, hysterectomy is not an acceptable therapeutical solution. More recently, hormone therapy and operative endoscopy laparoscopy and hysteroscopy have been introduced as alternatives, together with uterine embolisation previously applied preoperatively in extensive bleeding neoplasms or to control post-partum hemorrhage.

Adăugați în lista de dorințe Instalați Traduceți descrierea în română folosind Google Traducere? Infantile hemangiomas are benign vascular tumors composed of an increased number of unique endothelial cells that line blood vessels. They occur more frequently in female, premature and low birth weight infants. Infantile hemangiomas usually appear within the first weeks of life and grow most rapidly during the first three to six months of life. Usually, growth and proliferation is complete and involution commences by twelve months of age.

Segmentary myomectomy Benign cancer of blood vessels myomectomy is a conservative surgical intervention which consists in the resection of tumor, the preservation the uterus and, therefore, the reproductive function. In some cases, however, the intervention is difficult or impossible because of the dimension, position or number of existing fibromas.

Myomectomy is associated with increased blood loss, pain and prolonged operative time. It also has higher morbidity and mortality rates than hysterectomy.

Functional changes of cancerous cells in relation to normal cells

Furthermore, a significant number of patients undergoing myomectomy will need further surgical intervention. After intervention, a relapse of fibromatosis is likely to occur if there are small fibromas which have not been diagnosed clinically or imagistically before or during surgery and which continue to grow, eventually becoming symptomatic.

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Pre-surgery preoperatively arterial embolisation The embolisation of uterine arteries causes the devascularisation of all fibroma structures hpv cancer in mouth the uterus, which ensures optimal conditions for surgery.

The procedure consists in supraselective percutaneous catheterization of both uterine arteries followed by their embolisation with Polivinil alcohol particles PVA or Tachocomb fragments. The normal uterine structures are not affected, while the fibroma suffers an ischemy, necrosis and resorbtion process.

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Ideally, embolisation of large uterine fibroma must be followed by myomectomy. In case of pedunculated, subserosal fibromas, it is better that the embolisation be followed by myomectomy. The advantages of pre-surgery embolisation The embolisation performed a few days before surgery has numerous advantages: - Minimal surgery bleeding; - Eliminates the necessity for blood transfusion; - Surgical comfort; - Diminishes the duration of the surgery; - Allows resection of very large fibroma or of those positioned in areas difficult to reach the posterior side of the uterus, the inferior side close to the cervix.

Atypical mediastinal tumor

Through embolization, all the existing fibromas are devascularised, regardless of their dimensions and position. Papillon zeugma impresii fibroma structures which remain after surgery become necrotic and are resorbed during a period of several months.

The advantages of combined therapy Embolisation of uterus arteries followed by segmentary miomectomy is a conservative therapy, allowing the preservation of gestational function in cases where the usual treatment would have been hysterectomy.

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It is therefore, an important therapeutical option for young women, especially for those who wish to have children. The experience of our clinic: At the Bucharest Universitary Emergency Hospital, through the collaboration between the Obstetrics-Gynecology Clinic and the Angiography Laboratory of the Radiology Clinic from July until present, a number of embolisations were performed.

Therefore, it is the only clinic in Romania where the uterine arteries embolisation is performed. In this paper we describe three representative cases: - Case 1: large fibroma 9cm ; patient age: 20 years - Case 2: 4cm fibroma on the posterior side benign cancer of blood vessels the uterus, close to the cervix, with secondary infertility; patient age: 32 years - Case 3: uterine fibromatosis with numerous intramural and subserosal fibromas and a large nodule 10cm situated subserosal, with infertility.

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Case 1: single large uterine fibroma Patient M. Anamnesis: abundant and painful metroragies, urinary frequency, intraabdominal pressure. The patient underwent: a clinical gynaecological exam, pelvic ultrasound imaging, laboratory analysis, MRI. Therapy: supraselective embolisation of blood vessels supplying blood to the fibroma, followed by segmentary myomectomy.

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Embolisation of left-side uterine artery with Tachocomb fragments. During the first day after embolisation, myomectomy and drainage surgical intervention was decided and performed.

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In this case, a median pubo-subombilical incision was performed. The intraoperative histopathology exam result indicated an edematous transformed leiomyofibroma. The postoperative evolution of the patient was favorable, without complications.

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