Papillary thyroid carcinoma follicular variant histology. [Differentiated thyroid cancer--peculiar morphological and clinical forms].
Background: Thyroid nodules were reported with high prevalence in acromegalic patients.
Patients and methods: 63 acromegalic patients 16 males and 47 femalesaged at diagnosis Median duration of acromegaly was 8 years. Thyroid ultrasound was performed.
In suspected nodules, pathological examination either fine needle aspiration with cytology exam or pathology exam after thyroidectomy was performed. Results: Median thyroid volume was Thyroid nodules were present in 52 patients Multiple thyroid nodules were found in 45 out of 52 cases Toxic papillary thyroid carcinoma follicular variant histology goiter was prezent in 5 patients 7.
Average maximum diameter of dominant nodule was 1. Thyroid differentiated cancer was diagnosed in 6 patients 9.
Abstract Aim: to describe two cases of familial papillary thyroid carcinoma. Material and methods: patients were investigated by fine needle biopsy, MRI imaging and tumor biopsy, first case and histological examination of colonic and thyroid tumors first case and histological examination of thyroid tumor second case. Results and discussion: case presentation: first case, 68 years old man had a colonic polyposis attenuated form with only a few polyps and a thyroid nodule. After hemicolectomy for a supposed colonic carcinoma with liver and lung metastases, histological examination revealed no malignant colonic disease. Two month later the diagnosis of invasive thyroid tumor with lymph node metastases was made, but only an open biopsy was done because tumor invasiveness demonstrated on MTI imaging.
Histological type was papillary carcinoma: 3 macrocarcinomas and 3 microcarcinomas follicular variant of papillary carcinomas ; two microcarcinomas were multifocal. Five patients with thyroid carcinomas underwent thyroidectomy; 4 patients two macrocarcinomas and two multifocal microcarcinomas also papiloma humano brazo radioiodine treatment.
Thyroid surgery is pending in one patient. Autoimmune thyroiditis was present in 4 patients 6. Conclusion: Multinodular nontoxic thyroid disease was very frequent in our series of acromegalic patients.
We also found an increased prevalence of differentiated thyroid carcinoma. Careful clinical thyroid examination, thyroid ultrasound and cytological exam were recommended in acromegalic patients.