Departamentul 2 preclinic - Stiinte morfologice

Atypical papillary urothelial hyperplasia. Programe analitice - Anatomie patologica - UMF "Carol Davila"

At the center of the field are giant proerythroblast with intensely basophilic cytoplasm, a loose nuclear chromatin structure, and very large nucleoli.

cancer de piele sanse de vindecare papilloma vs neoplasm

This cell is several times larger than a normal erythroblast and is roughly the size of a megakaryocyte. This severe reduction of erythropoiesis in the bone marrow occurs mainly in children but may also develop in hemolytic anemias aplastic crisis.

atypical papillary urothelial hyperplasia oxiurose ciclo da doenca

Parvovirus B19 infection has been atypical papillary urothelial hyperplasia as the causal agent for the decreased erythropoiesis and consequent reticulocytopenia. The diagnosis is established by the presence of giant proerythroblasts in the bone marrow, which reach the size of megakaryocytes.

Most cases resolve spontaneously in 1 to 2 weeks. This phenomenon involves a syncytium-like aggregation of erythroblasts, which form pale cytoplasmic bridges at points of contact between the individual cells.

Urothelial Carcinoma

On electron microscopy it is characterized by the presence of septate-like membrane junctions between erythroblasts which are caused by a monoclonal immunoglobulin which is directed against an antigen of erythroblast membrane resulting in isolated severe anaemia with reticulocyto The Anemia in this case responded after therapy with corticosteroids.

The diagnosis may be atypical papillary urothelial hyperplasia by characteristic morphological appearance of bone marrow smears, and further confirmed by electron microscopy.

Ultrastructural examination of abnormal erythroblast clusters show that these cells were closely approximated with characteristic atypical papillary urothelial hyperplasia membrane junctions.

Mircea O.

Moreover, synartesis of normal erythroblasts were induced by the patient IgG fraction. Immunogold labeling showed that the monoclonal IgG were detected in, and restricted to, the synartesis.

atypical papillary urothelial hyperplasia

A discrete monoclonal plasmacytosis was also found in the patient bone marrow. The adhesion receptor CD36 appeared to be concentrated in the junctions, suggesting that it might be involved in virus papilloma test synartesis.

papillary urothelial tumors caracteristica virus papiloma humano

These experiments indicated that a monoclonal serum immunoglobulin IgG in the present cases directed at erythroblast membrane antigen was responsible for the erythroblast abnormalities. Specific therapy of the underlying lymphoproliferation was followed by complete remission of the anemia in these cases.

infeccion por oxiuros ninos