Tabloul clinic, stadiile și tratamentul cancerului de col uterin

Neuroendocrine cancer cervix, METACHRONOUS LUNG CANCER - CASE PRESENTATION | The Medical-Surgical Journal

One of the major tools to evaluate this type of pathology is the neuroendocrine markers as chromogranin A, serotonin, urinary 5-hydroxy indolacetic acid, and neuron specific enolase.

Specificații

They change related to the disease progression, regardless therapy. Some of the drugs that are used for NETs as somatostatin analogs for example octreotide might interfere with glucose metabolism.

neuroendocrine cancer cervix

We analyzed in a retrospective study of 2 years the dynamic of the NET markers and the glycemia profile. Material and Methods. All the patients had at least one assay per year. The dose of octreotide varied from 20 to 50 mg, monthly. The fasting glucose insignificantly changed from baseline after 2 years.

Cervical Cancer Staging

No new case of diabetes was registered. One case of known diabetes needed insulin but interferon therapy was also added during this time period. The chromogranin A had sustained high values for all the 9 cases, marking the disease progression. The neuron specific enolase significantly increased, and the serum serotonin as well as the neuroendocrine cancer cervix was much higher in 2 cases with aggressive carcinoid symptoms.

The NET markers and the glucose metabolism are most useful tools in the management of NETs, yet they are not correlated. Rezumat Tumorile neuroendocrine NET sunt mult mai frecvente în ultimele decade.

Revista Romana de Medicina de Laborator

Unul din intrumentele majore de evaluare în această patologie este reprezentat de dozarea markerilor neuroendocrini precum cromogranina Cancer colorectal univ, serotonina, acidul 5-hidroxi indolacetic urinar şi enolaza neuronal neuroendocrine cancer cervix.

Aceştia se schimbă cu progresia tumorală, indiferent de terapie. O parte din medicamentele folosite în NET precum analogii de somatostatin de exemplu, octreotid interferă cu metabolismul glucozei. Am analizat într-un studiu retrospectiv de-a neuroendocrine cancer cervix a 2 ani dinamica markerilor NET şi profilul glicemic.

Abstract Multiple primary tumors can be synchronous when detected simultaneously or metachronous when detected after a variable time interval. We present the case of a year-old female patient with a history of keratinized squamous cell carcinoma of the cervix, stage T3bNxMx, operated, and treated by chemotherapy and radiation therapy which develops after three years a large cell neuroendocrine carcinoma of the lung detected by imaging.

Material si metode. Toţi pacienţii au avut cel puţin o evaluare pe an.

neuroendocrine cancer cervix

Doza de octreotid a variat de la 20 la 50 mg lunar. Glicemia s-a modificat nesemnificativ de la bază după 2 ani. Nu s-a înregistrat nici un caz nou de diabet.

Tabloul clinic, stadiile și tratamentul cancerului de col uterin

O pacientă a necesitat insulină pentru diabetul preexistent dar între timp s-a adaugat şi terapie cu interferon Cromogranina A a avut valori mari sustinute pentru toate cele 9 cazuri, sugerând progresia bolii. Enolaza neuronal specifică a crescut semnificativ iar serotonina serică şi 5HIIA au crescut considerabil în 2 cazuri cu simptome severe de sindrom carcinoid. Markerii NET şi metabolismul glucidic sunt instrumente foarte utile in managementul tumorilor neuroendocrine, totusi acestea nu se coreleaza.

anemie cu celule in secera

Cuvinte cheie: cromogranina A ; tumora neuroendocrina ; serotonina References 1. Neuroendocrine tumors. Endocr Relat Cancer. DOI: Oberndorfer S.

Karzinoide tumoren des dunndarms. Frank Z Pathol. Google Scholar 3. Carcinoid Tumors. Bellizzi AM. Assigning site of origin neuroendocrine cancer cervix metastatic neuroendocrine neoplasms: a clinically significant application of diagnosis immunohistochemistry.

Adv Anat Pathol.

neuroendocrine cancer cervix

Chromogranins A, B, C: widespread consitituents of secretory vesicles. Ann N Y Acad Sci. Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors.

Regul Pept. The poor prognosis factors in G2 neuroendocrine tumor. Rom J Morphol Embryol. Google Scholar The dedifferentiation of neuroendocrine tumor metastases: myth or reality?

Diagnostic Pathology: Cytopathology

PubMed Google Scholar cancerul cerebral Octreotide for the treatment neuroendocrine cancer cervix hypoglycemia after insulin glargine overdose. J Emerg Med. Biochemical testing for neuroendocrine tumors.

Teste de autoevaluare Tabloul clinic, stadiile și tratamentul cancerului de col uterin Tabloul clinic și paternul de creştere a cancerului de col uterin invaziv este variabil. Neuroendocrine cancer cervix poate fi polipoidă, papilomatoasă sau fungoasă, sau ea poate fi netedă sau ulcerativă Figura 4. Inițial, majoritatea formelor de cancere au o creștere local-infiltrativă; ulterior se extind spre corpul uterului, în jos în vagin sau lateral în fornixurile pelviene. În cele din urmă tumoarea poate afecta organele adiacente, cum ar fi vezica urinară sau rectul și eventual poate avea loc răspăndirea metastatică spre ficat și alte organe la distanță.

The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am ;40 1 Well-differentiated neuroendocrine tumor and osteoporosis: incidental finding? Treatment of malignant midgut carcinoid tumours with a long-acting somatostatin analogue octreotide. Acta Oncol. Long-term clinical outcome of somatostatin analogues for treatment of pregressive, metastatic, well-differentiated entero-pancreatic endocrine carcinoma.

Ann Oncol. Predictive factors of efficacy of the somatostatin analogue octreotide as first line therapy for advanced pancreatic endocrine carcinoma.