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Neuroendocrine cancer with mets

Revista Romana de Medicina de Laborator

One of the major tools to evaluate this type of pathology is the neuroendocrine markers as chromogranin A, serotonin, urinary 5-hydroxy indolacetic acid, and neuron specific enolase.

They change related to the disease progression, regardless therapy. Some of the drugs that are used for NETs as somatostatin analogs for example octreotide might interfere with glucose metabolism. We analyzed in a retrospective study of 2 years the neuroendocrine cancer with mets of the NET markers and the glycemia profile.

Material and Methods. All the patients had at least one assay per year.

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The dose of octreotide varied from 20 to 50 mg, monthly. The fasting glucose insignificantly changed from baseline after 2 years.

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No new case of diabetes was registered. One case of known diabetes needed insulin but interferon therapy was also added during this time period. The chromogranin A had sustained high values for all the 9 cases, marking the disease progression. The neuron specific enolase significantly increased, and the serum serotonin as well as the 5HIIA was much higher in 2 cases with aggressive carcinoid symptoms.

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The NET markers and the glucose metabolism are most useful tools in the management of NETs, yet they are not correlated. Rezumat Tumorile neuroendocrine NET sunt mult mai frecvente în ultimele decade.

This article provides an overview of the current state of the imaging modalities used for primary tumor visualization, staging and follow-up.

Unul din intrumentele majore de evaluare în această patologie este reprezentat de dozarea markerilor neuroendocrini precum cromogranina A, serotonina, acidul 5-hidroxi indolacetic urinar şi enolaza neuronal specifică. Aceştia se schimbă cu progresia tumorală, indiferent de terapie. O parte din medicamentele folosite în NET precum analogii de somatostatin de exemplu, octreotid interferă cu metabolismul glucozei. Am analizat într-un studiu retrospectiv de-a lungul a 2 ani dinamica markerilor NET şi profilul glicemic.

Material si metode.

NEUROENDOCRINE TUMORS: CHOOSING APPROPRIATE IMAGING METHODS

Toţi pacienţii au avut cel puţin o evaluare pe an. Doza de octreotid a variat de la 20 la 50 mg lunar.

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Glicemia s-a modificat parazitii sindromul tourette de la neuroendocrine cancer with mets după 2 ani. Nu s-a înregistrat nici un caz nou de diabet. O pacientă a necesitat insulină pentru diabetul preexistent dar între timp s-a adaugat şi terapie cu interferon Cromogranina A a avut valori mari sustinute pentru toate cele 9 cazuri, sugerând progresia bolii. Enolaza neuronal specifică a crescut semnificativ iar serotonina serică şi 5HIIA au crescut considerabil în 2 cazuri cu simptome severe de sindrom carcinoid.

Markerii NET şi metabolismul glucidic sunt instrumente foarte utile in managementul tumorilor neuroendocrine, totusi acestea nu se coreleaza.

MATERIALS AND METHODS: Imaging studies of 22 patients 12 men, mean age 60 years with histopathologically confirmed diagnosis, evaluated in the authors's institution during the last five years were retrospectively reviewed by two radiologists, with findings being consensually described focusing on changes observed at computed tomography. Only one typical carcinoid presented the characteristic appearance of central endobronchial nodule with distal pulmonary atelectasis, while the others were pulmonary nodules or masses. The atypical carcinoids corresponded to peripheral heterogeneous masses. One out of the three LCNCs was a peripheral homogeneous mass, while the others were ill-defined and heterogeneous. The 11 SCLCs corresponded to central, infiltrating and heterogeneous masses with secondary pleuropulmonary changes.

Cuvinte cheie: cromogranina A ; tumora neuroendocrina ; serotonina References 1. Neuroendocrine tumors. Endocr Relat Cancer.

DOI: Oberndorfer S. Karzinoide tumoren des dunndarms.

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Frank Z Pathol. Google Scholar 3.

Neuroendocrine tumours (NETs): symptoms, diagnosis and treatment

Carcinoid Tumors. Bellizzi AM.

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