Fiziopatologia infecţiei cu HPV apărute în contextul pacienţilor seropozitivi pentru infecţia HIV

Hpv related carcinoma.

Conținutul

    Department of Ophthalmology, Grigore T.

    E-mail: moc. We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye. The method used for the detection of HPV was real time polymerase chain reaction.

    Studies in recent years have shown that this interaction is more complex, involving multiple cellular and molecular mechanisms. Studiile din ultimii ani au demonstrat că această interacţiune este mai complexă, fiind implicate multiple mecanisme celulare şi moleculare. Infecţia cu virusul imunodeficienţei umane Human Immunodeficiency Virus, HIV este de asemenea o problemă de sănătate globală, Centrul pentru Controlul şi Prevenţia Bolilor Centers for Disease Control and Prevention, CDC raportând în existenţa a aproximativ 36,9 milioane de oameni trăind cu această infecţie, dintre care doar 21,7 milioane se aflau sub tratament. Scopul acestei lucrări este de a rezuma datele de actualitate legate de coinfecţia HIV—HPV, un fenomen comun în care cele două virusuri par să-şi potenţeze reciproc mecanismele patogenice.

    The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence. Keywords: Conjunctiva, eye, human papillomavirus 52, real time polymerase hpv related carcinoma reaction, squamous cell carcinoma Human papillomavirus HPV infection is strongly associated with anogenital tumors cervix, penis, vulva, vagina, anushead and neck cancers oral cavity, esophagus, larynxand nonmelanoma skin cancers squamous and basal cell carcinoma.

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    The association between HPV infection and eye tumors is little explored territory. Di Girolamo brings forward a two-hit theory that explains cancerogenesis in OSSN: The first hit cancer ganglions hodgkin stade 4 mediated by ultraviolet radiation exposure that causes genetic alteration and the second hpv related carcinoma is mediated by HPV infection in the susceptible cells.

    Case Report We present a unique case of squamous cell carcinoma of hpv related carcinoma conjunctiva examined and treated in June The year-old patient presented at the Ophthalmology Department for mild stinging sensation and redness in the left eye for almost 1-year and a half.

    hpv related carcinoma papilloma in corner of eye

    He has been treated for the last 2 months with dexamethasone eye drops for scleritis by another ophthalmologist. The patient admits being a heavy smoker for almost 30 years and that in his free time hpv related carcinoma practices agriculture without using sunglasses.

    All other ophthalmological findings were normal.

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    Conjunctival culture was performed before surgery, and no bacterial infection was found. The CT scan of the head and neck showed no signs of tumor invasion of the orbit or hpv related carcinoma lymph nodes.

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    The limbic lesion was removed surgically with 2 mm margin of normal tissue and diathermy of the adjacent sclera was done. At the hpv related carcinoma, the remaining temporal defect was restored using a supero-nasal conjunctiva graft fixed in position with interrupted and surjet The excised tumor was cut into 2 fragments: One for pathology preserved in formalin and one for HPV genotyping preserved in Cobas polymerase chain reaction PCR solution and refrigerated at 4°C until processing.

    Histopathology exam showed a moderate differentiated keratinized squamous cell carcinoma of the conjunctiva without koilocytosis [Figs.

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