Cancer colon stage 4
Source: Clujul Medical.
Sep Supplement, p Abstract: Introduction:Lymph node status is the most important predictive factor in cancer of the colon. Sentinel node biopsy can proceed colon cancer from stage I to stage II, with consequences in the postoperative treatment. Adjuvant chemotherapy indicated in cases with nodal invasion significantly improves survival.
Materials and methods:We used peritumoral subserosal injection of methylene blue dye for SLN identification, in cases of 40 patients operated with colon cancer in the First Surgery Clinic of County Hospital Mures. Whe used to detect metastases histological examination hematoxylin-eosin stain HE. If the sentinel lymph node was negative pN0 in routine staining with hematoxylin-eosin whe performed immunohistochemical examination with citokeratin IHC.
In Romania, the incidence of CRC in is We reviewed a series of studies that are related to colon cancer and studied the epithelial-mesenchymal transition at the front of tumor invasion EMT. Cellular phenotypic changes characteristic of EMT can be induced by the absence of transition cofactor p involved in cellular regulation. Loss of syndecan-1 marker is associated with local tumor stage and metastasis. Modulators of protein kinase resistance was associated with changes in genes involved in EMT including vimentin hyperexpression and genes involved in invasion N-cadherin with a decrease expression of genes involved in epithelial cell adhesion E-cadherin.
A total of lymph nodes were examined, of them have branded as a total of 76 sentinel nodes in average 1. Conclusions:The use of sentinel lymph node examination and its identification using methylene blue is a feasible and accurate method. Whe performed upstaging using immunohistochemistry IHC in 9 cases Biopsy sentinel node can proceed colon cancer cancer colon stage 4 stage I to stage II, with consequences in the postoperative treatment.
The clinical value method treatment effectiveness will be assessed by benefits of postoperative chemotherapy in these patients. English Copyright of Clujul Medical is the property of Cluj Medical University and its content may cancer colon stage 4 be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission.
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